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Redefining immune cell therapy through circularity



Transforming RNA innovation into the power of life.


 

We Are Visionaries

At BiosynRNA, we see beyond today’s challenges.
We believe circRNA will redefine the foundation of medicine—offering safer, longer-lasting, and more versatile therapies.

 

Driven by creativity and scientific excellence, we are building technologies that turn molecular innovation into accessible treatments for every patient, everywhere.

Image by National Cancer Institute
Image by Louis Reed
Image by National Cancer Institute

Let’s Plug and Play 

BiosynRNA’s Syn-TX™ platform rapidly adapts proteins or antibodies for precise immune cell targeting, integrating with our advanced circRNA design and scalable manufacturing for customizable in vivo CAR-T and immune therapies.

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Explore Our Pipelines
From circRNA-based in vivo CAR-T therapies to next-generation immune modulators, BiosynRNA is advancing a diverse portfolio of RNA therapeutics from design to clinical translation.

Technology

Our integrated technology pipeline bridges discovery and therapy. 

1

Syn-Gen™ | AI-Driven circRNA Design

Syn-Gen™ integrates artificial intelligence with molecular modeling to rationally design circular RNA sequences that achieve optimal translation, minimal immunogenicity, and precise control of expression duration.
This platform transforms RNA design from trial-and-error into a data-driven, programmable process—accelerating therapeutic development across multiple disease targets.

Image by Steve Johnson

2

Syn-O™ | Advanced Circularization System 

Syn-O™ leverages a newly discovered  Group I intron–based PIE mechanism to achieve high-efficiency circularization with simplified purification.
This next-generation RNA circularization system features enhanced catalytic activity and sequence flexibility, enabling rapid adaptation for diverse therapeutic constructs and providing a robust backbone for all BiosynRNA circRNA products.

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3

Syn-TX™ | Targeted Delivery Platform

Syn-TX™ employs a modular lipid nanoparticle (LNP) and protein-fusion architecture to achieve cell-specific delivery of circRNA payloads.
This next-generation delivery system enables in vivo applications such as CAR-T and immune-modulatory therapies, expanding the boundaries of RNA medicine beyond conventional ex vivo approaches.

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4

Syn-Mega™ | GMP-Grade Manufacturing Platform

Syn-Mega™ introduces a proprietary enzymatic and FPLC-coupled purification workflow that enables large-scale production of ultra-pure circRNA with exceptional consistency and yield.
By bridging research-grade synthesis and industrial-scale manufacturing, it sets a new standard for clinical-ready RNA therapeutics.

Image by TECNIC Bioprocess Solutions

Our Pipelines

Innovating, Engineering, Empowering.

PROGRAM

SYNCAR-100

B cell Acute Lymphoblastic Leukemia
 

SYNCAR-101

Lymphoma
 

SYNCAR-102
 

Systemic Lupus Erythematosus
 

SYNCAR-104

Systemic Sclerosis
 

SYNTR-100

B cell Acute Lymphoblastic Leukemia
 

SYNGLP

Weight Loss
 

PRECLINICAL

CLINICAL TRAIL (IIT/PHASE I)

CLINICAL TRAIL (PHASE II)

Press

To be Announced 

BIOSYNRNA
November 2025

To Be Announced

Biotech Frontier Review
May 2025

To be Announced

IBRM Magazine
March 2025

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